Effective Oral Administration of an Antitumorigenic Nanoformulated Titanium Complex

Gilad Nahari, Ori Braitbard, Liraz Larush, Jacob Hochman, Edit Y. Tshuva

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Abstract: Orally administered anticancer drugs facilitate treatment, but the acidic conditions in the stomach often challenge their availability. PhenolaTi is a TiIV-based nontoxic anticancer drug with marked in-vivo efficacy. We report that nanoformulation protects phenolaTi from decomposition in stomach-like conditions. This is evidenced by similar NMR characteristics and similar in-vitro cytotoxicity toward murine (CT-26) and human (HT-29) colon cancer cells before and after incubation of nanoformulated phenolaTi (phenolaTi-F) at pH 2, unlike results with the unformulated form of the complex. Furthermore, administration of phenolaTi-F in animal drinking water revealed a notable inhibition of tumor growth in Balb/c and immune-deficient (Nude) mice inoculated with CT-26 and HT-29 cells, respectively. In-vivo efficacy was at least similar to that of the corresponding intraperitoneal treatment with phenolaTi-F and the clinically employed oral drug, capecitabine. No body weight loss or clinical signs of toxicity were evident in the phenolaTi-F-treated animals. These findings demonstrate a new convenient mode of cancer treatment through oral administration by safe titanium-based drugs.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalChemMedChem
Volume16
Issue number1
DOIs
StatePublished - 8 Jan 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

Funding was received from the European Research Council (ERC) under the European Union's Horizon 2020 research (grant agreement no. 779689 to E.Y.T.)

FundersFunder number
European Union's Horizon 2020 research779689
Horizon 2020 Framework Programme681243
European Research Council

    Keywords

    • antitumor agents
    • metallodrug
    • nanoformulations
    • oral administration
    • titanium

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