Effect of the inhibitory material from male genital tract on natural killing activities

Z. H. Marcus; F. Dondero; B. Lunenfeld; L. M. Lewin

doi:10.1016/0165-2478(85)90041-0

Effect of the inhibitory material from male genital tract on natural killing activities

Z. H. Marcus, F. Dondero, B. Lunenfeld, L. M. Lewin

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A male inhibitory material (HuSePl-Frl) was separated from normal human seminal plasma by gel filtration on Sephadex G-100. This material has high avidity for cell membranes of human red blood cells (RBC). In vitro, PHA-M-induced blast transformation of human lymphocytes is inhibited by small quantities of HuSePl-Frl. This inhibition was also evident when RBC coated with HuSePl-Frl is added to mitogen stimulated lymphocytes in cultures. Small quantities of HuSePl-Frl are inhibitory to natural killer (NK) cell activation. The modulating role of the HuSePl-Frl in preventing the spermatozoal rejection during fertilization is discussed.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Immunology Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(85)90041-0
State	Published - 1985
Externally published	Yes

Keywords

male genital tract inhibitory material - natural killer activity

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10.1016/0165-2478(85)90041-0

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abstract = "A male inhibitory material (HuSePl-Frl) was separated from normal human seminal plasma by gel filtration on Sephadex G-100. This material has high avidity for cell membranes of human red blood cells (RBC). In vitro, PHA-M-induced blast transformation of human lymphocytes is inhibited by small quantities of HuSePl-Frl. This inhibition was also evident when RBC coated with HuSePl-Frl is added to mitogen stimulated lymphocytes in cultures. Small quantities of HuSePl-Frl are inhibitory to natural killer (NK) cell activation. The modulating role of the HuSePl-Frl in preventing the spermatozoal rejection during fertilization is discussed.",

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year = "1985",

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AU - Marcus, Z. H.

AU - Dondero, F.

AU - Lunenfeld, B.

AU - Lewin, L. M.

PY - 1985

Y1 - 1985

N2 - A male inhibitory material (HuSePl-Frl) was separated from normal human seminal plasma by gel filtration on Sephadex G-100. This material has high avidity for cell membranes of human red blood cells (RBC). In vitro, PHA-M-induced blast transformation of human lymphocytes is inhibited by small quantities of HuSePl-Frl. This inhibition was also evident when RBC coated with HuSePl-Frl is added to mitogen stimulated lymphocytes in cultures. Small quantities of HuSePl-Frl are inhibitory to natural killer (NK) cell activation. The modulating role of the HuSePl-Frl in preventing the spermatozoal rejection during fertilization is discussed.

AB - A male inhibitory material (HuSePl-Frl) was separated from normal human seminal plasma by gel filtration on Sephadex G-100. This material has high avidity for cell membranes of human red blood cells (RBC). In vitro, PHA-M-induced blast transformation of human lymphocytes is inhibited by small quantities of HuSePl-Frl. This inhibition was also evident when RBC coated with HuSePl-Frl is added to mitogen stimulated lymphocytes in cultures. Small quantities of HuSePl-Frl are inhibitory to natural killer (NK) cell activation. The modulating role of the HuSePl-Frl in preventing the spermatozoal rejection during fertilization is discussed.

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Effect of the inhibitory material from male genital tract on natural killing activities

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Keywords

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