Effect of progesterone injection on progesterone receptor levels and distribution in untreated and short-term Premarin-primed pre-menopausal and post-menopausal endometrium

I. G. Gorodeski, A. Geier, B. Lunenfeld, A. Sigal, R. Beery, D. Serr, C. M. Bahary

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cytosolic and nuclear progesterone receptors (RPC, RPN) were measured in post-menopausal endometria, using [3H]R5020 as the radioligand, and the findings compared with those in pre-menopausal endometria. Total RP levels (RPC + RPN) in post-menopausal endometria were low, i.e. < 2000 fmol/mg DNA. A 7-11 day course of Premarin (conjugated equine oestrogen) treatment in post-menopausal subjects resulted in RP levels in 11818 ± 3008 fmol/mg DNA, which were higher than those in proliferative, mid-cycle and Premarin-primed pre-menopausal endometria. Progesterone injection 1-3 h before tissue collection resulted in a change in the distribution of the RP in both premenopausal and post-menopausal Premarin-primed endometria and pre-menopausal proliferative and mid-cycle endometria. Following the progesterone injection RPN levels increased to 57±9% of the total as compared with 23±8% in endometrial samples from women who received no progesterone.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalMaturitas
Volume8
Issue number4
DOIs
StatePublished - Dec 1986
Externally publishedYes

Keywords

  • Cytosolic
  • Endometrium
  • Nuclear
  • Progesterone receptors

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