Abstract
Cytosolic and nuclear progesterone receptors (RPC, RPN) were measured in post-menopausal endometria, using [3H]R5020 as the radioligand, and the findings compared with those in pre-menopausal endometria. Total RP levels (RPC + RPN) in post-menopausal endometria were low, i.e. < 2000 fmol/mg DNA. A 7-11 day course of Premarin (conjugated equine oestrogen) treatment in post-menopausal subjects resulted in RP levels in 11818 ± 3008 fmol/mg DNA, which were higher than those in proliferative, mid-cycle and Premarin-primed pre-menopausal endometria. Progesterone injection 1-3 h before tissue collection resulted in a change in the distribution of the RP in both premenopausal and post-menopausal Premarin-primed endometria and pre-menopausal proliferative and mid-cycle endometria. Following the progesterone injection RPN levels increased to 57±9% of the total as compared with 23±8% in endometrial samples from women who received no progesterone.
Original language | English |
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Pages (from-to) | 353-358 |
Number of pages | 6 |
Journal | Maturitas |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1986 |
Externally published | Yes |
Keywords
- Cytosolic
- Endometrium
- Nuclear
- Progesterone receptors