Abstract
Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymers exhibit a sol–gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20% w/w) is described. All polymer solutions convert into a hard gel within 2 °C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW.
| Original language | English |
|---|---|
| Pages (from-to) | 35-39 |
| Number of pages | 5 |
| Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
| Volume | 57 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 Wiley Periodicals, Inc.
Funding
This work was supported by a grant from the Israel Cancer Research Fund (ICRF). This study was supported by an International Collaboration Grant from the Jacki and Bruce Barron Cancer Research Scholars’ Program, a partnership of the ICRF and City of Hope, as supported by The Harvey L. Miller Family Foundation. This work was supported by a grant from the Israel Cancer Research Fund (ICRF). This study was supported by an International Collaboration Grant from the Jacki and Bruce Barron Cancer Research Scholars' Program, a partnership of the ICRF and City of Hope, as supported by The Harvey L. Miller Family Foundation.
| Funders | Funder number |
|---|---|
| Harvey L. Miller Family Foundation | |
| Israel Cancer Research Fund | |
| City, University of London |
Keywords
- PEG-PLGA
- biodegradable polymers
- copolymerization
- drug delivery systems
- hydrogels
- thermoresponsive hydrogels