Effect of intensive insulin treatment on linear growth in the young diabetic patient

Although impaired growth is a well-recognized complication of uncontrolled diabetes, it has not been established whether less servere metabolic derangements commonly seen with conventional treatment adversely affect growth potential. To examine this question, growth velocity was measured in nine type 1 diabetic patients (age 14±3 years) before and after six months of intensive insulin treatment either with the insulin pump or with multiple injections, which lowered mean plasma glucose concentration from 270±96 to 105±55 mg/dl and total glycosylated hemoglobin from 12.4±3.0 to 8.4±1.5% (mean ±SD). During conventional treatment, growth velocity (5.3±2.2 cm/year) was within the range of normal despite elevations in plasma glucose concentrations. However, growth velocity increased sharply during intensive treatment (to 9.4±3.9 cm/year, P<0.005), reaching values in excess of normal in seven patients. The increase in growth velocity observed during intensive treatment was associated with a twofold rise in plasma somatomedin-C values. Skeletal maturation, previously normal or slightly delayed, did not advance excessively. These data indicate that the metabolic changes accompanying intensive treatment may enhance growth in diabetic children, even in those with apparently normal growth velocity during conventional therapy.