TY - JOUR
T1 - Effect of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury
AU - Rogatsky, Gennady G.
AU - Kamenir, Yury
AU - Mayevsky, Avraham
N1 - Funding Information:
This study was supported by a grant from the Leslie and Susan Gonda (Goldshmied) Brain Research Center, Bar-Ilan University.
PY - 2005/6/21
Y1 - 2005/6/21
N2 - Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO2) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO2 treatment has a therapeutic effect on ICP dynamics and survival following severe fluid percussion brain injury (FPBI) in rats. Changes in ICP level were analyzed every 30 min during an 8-h monitoring period following trauma and at the end of experiment (20 h). The control (A) and experimental (B) groups consisted of 7 and 4 rats, respectively. Group B was subjected to 1.5 atmospheres absolute (ATA) 100% oxygen for 60 min beginning 2 h after FPBI. No significant differences in ICP were noted between groups A and B before and after HBO2 treatment until 3.5 h after trauma. At 4 h, for the first time, the difference became significant (P = 0.025; n = 11) and remained significant (P < 0.05) for all measurement points until end of monitoring, when mean ICP values reached 37.17 ± 14.25 and 20.25 ± 2.63 mm Hg in groups A and B, respectively. Linear approximation models showed different trends (b1 = 3.80 ± 0.23; r2 = 0.65, P < 0.001 and b1 = 1.56 ± 0.25; r2 = 0.77, P < 0.001) for groups A and B, respectively. Covariance analysis confirmed significant differences between slopes for groups A and B (F = 148.04, P < 0.001; df = 2,177), i.e., a significant difference in mean rate of ICP elevation. By the end of the experiment, 3 out of 7 rats from group A had died, but none from group B. We conclude that the application of HBO2 during the early phase of severe FPBI significantly diminished ICP elevation rate and decreased mortality level.
AB - Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO2) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO2 treatment has a therapeutic effect on ICP dynamics and survival following severe fluid percussion brain injury (FPBI) in rats. Changes in ICP level were analyzed every 30 min during an 8-h monitoring period following trauma and at the end of experiment (20 h). The control (A) and experimental (B) groups consisted of 7 and 4 rats, respectively. Group B was subjected to 1.5 atmospheres absolute (ATA) 100% oxygen for 60 min beginning 2 h after FPBI. No significant differences in ICP were noted between groups A and B before and after HBO2 treatment until 3.5 h after trauma. At 4 h, for the first time, the difference became significant (P = 0.025; n = 11) and remained significant (P < 0.05) for all measurement points until end of monitoring, when mean ICP values reached 37.17 ± 14.25 and 20.25 ± 2.63 mm Hg in groups A and B, respectively. Linear approximation models showed different trends (b1 = 3.80 ± 0.23; r2 = 0.65, P < 0.001 and b1 = 1.56 ± 0.25; r2 = 0.77, P < 0.001) for groups A and B, respectively. Covariance analysis confirmed significant differences between slopes for groups A and B (F = 148.04, P < 0.001; df = 2,177), i.e., a significant difference in mean rate of ICP elevation. By the end of the experiment, 3 out of 7 rats from group A had died, but none from group B. We conclude that the application of HBO2 during the early phase of severe FPBI significantly diminished ICP elevation rate and decreased mortality level.
KW - Fluid percussion brain injury
KW - HBO
KW - Intracranial pressure
UR - http://www.scopus.com/inward/record.url?scp=20444429363&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2005.02.049
DO - 10.1016/j.brainres.2005.02.049
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C2 - 15904900
AN - SCOPUS:20444429363
SN - 0006-8993
VL - 1047
SP - 131
EP - 136
JO - Brain Research
JF - Brain Research
IS - 2
ER -