Abstract
Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO2) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO2 treatment has a therapeutic effect on ICP dynamics and survival following severe fluid percussion brain injury (FPBI) in rats. Changes in ICP level were analyzed every 30 min during an 8-h monitoring period following trauma and at the end of experiment (20 h). The control (A) and experimental (B) groups consisted of 7 and 4 rats, respectively. Group B was subjected to 1.5 atmospheres absolute (ATA) 100% oxygen for 60 min beginning 2 h after FPBI. No significant differences in ICP were noted between groups A and B before and after HBO2 treatment until 3.5 h after trauma. At 4 h, for the first time, the difference became significant (P = 0.025; n = 11) and remained significant (P < 0.05) for all measurement points until end of monitoring, when mean ICP values reached 37.17 ± 14.25 and 20.25 ± 2.63 mm Hg in groups A and B, respectively. Linear approximation models showed different trends (b1 = 3.80 ± 0.23; r2 = 0.65, P < 0.001 and b1 = 1.56 ± 0.25; r2 = 0.77, P < 0.001) for groups A and B, respectively. Covariance analysis confirmed significant differences between slopes for groups A and B (F = 148.04, P < 0.001; df = 2,177), i.e., a significant difference in mean rate of ICP elevation. By the end of the experiment, 3 out of 7 rats from group A had died, but none from group B. We conclude that the application of HBO2 during the early phase of severe FPBI significantly diminished ICP elevation rate and decreased mortality level.
Original language | English |
---|---|
Pages (from-to) | 131-136 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 1047 |
Issue number | 2 |
DOIs | |
State | Published - 21 Jun 2005 |
Bibliographical note
Funding Information:This study was supported by a grant from the Leslie and Susan Gonda (Goldshmied) Brain Research Center, Bar-Ilan University.
Funding
This study was supported by a grant from the Leslie and Susan Gonda (Goldshmied) Brain Research Center, Bar-Ilan University.
Funders | Funder number |
---|---|
Leslie and Susan Gonda |
Keywords
- Fluid percussion brain injury
- HBO
- Intracranial pressure