Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats

M. Krakovsky; G. Rogatsky; N. Zarchin; A. Mayevsky

doi:10.1016/s0090-3019(97)00195-x

Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats

M. Krakovsky, G. Rogatsky, N. Zarchin, A. Mayevsky

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

BACKGROUND: Hyperbaric oxygenation (HBO) has been considered for many years for the treatment of severe brain ischemia. However, its efficacy has not been proven. The aim of this study was to shed light on this question. METHODS: Acute global cerebral ischemia was induced in 18 rats using the four-vessel occlusion model. Regional cerebral blood flow (CBF) was determined by laser-Doppler flowmetry using a flexible 1 mm fiberoptic probe. Two stainless steel screws were used to measure the spontaneous electrical activity from the contralateral hemisphere. After ischemia monitored by laser-Doppler flowmetry and ECoG, the animals were divided into two groups: (1) control animals that breathed air at atmospheric pressure and (2) rats exposed to HBO at three atmospheres absolute pressure (ATA) for 1 hour. Survival time and rate were recorded for both groups of animals for 14 days. RESULTS: The survival rate in the study group was significantly higher (45%) than in the control group (0%). In the animals that did not survive the 14- day period, those exposed to HBO survived longer than the control animals (59.8 ± 9.1 hour versus 17.9 ± 2.7 hours, p < 0.05). CONCLUSION: This investigation demonstrates that HBO administered after global cerebral ischemia can increase survival in a rat stroke model.

Original language	English
Pages (from-to)	412-416
Number of pages	5
Journal	Surgical Neurology
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/s0090-3019(97)00195-x
State	Published - Apr 1998

Bibliographical note

Funding Information:
This work was supported by a grant from the Israel Science Foundation administrated by the Israel Academy of Sciences and Humanities. The authors thank Dr. E. Guggenheimer-Furman for helpful suggestions and corrections of the manuscript.

Funding

This work was supported by a grant from the Israel Science Foundation administrated by the Israel Academy of Sciences and Humanities. The authors thank Dr. E. Guggenheimer-Furman for helpful suggestions and corrections of the manuscript.

Funders	Funder number
Israel Academy of Sciences and Humanities
Israel Science Foundation

Keywords

Brain ischemia
Hyperbaric oxygen
Protective effect
Rat

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10.1016/s0090-3019(97)00195-x

Cite this

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title = "Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats",

abstract = "BACKGROUND: Hyperbaric oxygenation (HBO) has been considered for many years for the treatment of severe brain ischemia. However, its efficacy has not been proven. The aim of this study was to shed light on this question. METHODS: Acute global cerebral ischemia was induced in 18 rats using the four-vessel occlusion model. Regional cerebral blood flow (CBF) was determined by laser-Doppler flowmetry using a flexible 1 mm fiberoptic probe. Two stainless steel screws were used to measure the spontaneous electrical activity from the contralateral hemisphere. After ischemia monitored by laser-Doppler flowmetry and ECoG, the animals were divided into two groups: (1) control animals that breathed air at atmospheric pressure and (2) rats exposed to HBO at three atmospheres absolute pressure (ATA) for 1 hour. Survival time and rate were recorded for both groups of animals for 14 days. RESULTS: The survival rate in the study group was significantly higher (45%) than in the control group (0%). In the animals that did not survive the 14- day period, those exposed to HBO survived longer than the control animals (59.8 ± 9.1 hour versus 17.9 ± 2.7 hours, p < 0.05). CONCLUSION: This investigation demonstrates that HBO administered after global cerebral ischemia can increase survival in a rat stroke model.",

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author = "M. Krakovsky and G. Rogatsky and N. Zarchin and A. Mayevsky",

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AU - Rogatsky, G.

AU - Zarchin, N.

AU - Mayevsky, A.

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N2 - BACKGROUND: Hyperbaric oxygenation (HBO) has been considered for many years for the treatment of severe brain ischemia. However, its efficacy has not been proven. The aim of this study was to shed light on this question. METHODS: Acute global cerebral ischemia was induced in 18 rats using the four-vessel occlusion model. Regional cerebral blood flow (CBF) was determined by laser-Doppler flowmetry using a flexible 1 mm fiberoptic probe. Two stainless steel screws were used to measure the spontaneous electrical activity from the contralateral hemisphere. After ischemia monitored by laser-Doppler flowmetry and ECoG, the animals were divided into two groups: (1) control animals that breathed air at atmospheric pressure and (2) rats exposed to HBO at three atmospheres absolute pressure (ATA) for 1 hour. Survival time and rate were recorded for both groups of animals for 14 days. RESULTS: The survival rate in the study group was significantly higher (45%) than in the control group (0%). In the animals that did not survive the 14- day period, those exposed to HBO survived longer than the control animals (59.8 ± 9.1 hour versus 17.9 ± 2.7 hours, p < 0.05). CONCLUSION: This investigation demonstrates that HBO administered after global cerebral ischemia can increase survival in a rat stroke model.

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Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats

Abstract

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