EFFECT OF HUMAN MENOPAUSAL GONADOTROPINS ON OVARIAN FOLLICULAR SELECTION AND HYPERSTIMULATION IN WOMEN.

In order to answer the question whether human-menopausa-gonadotropins (HMG) can override the normal mechanism of ovarian follicular selection, we administered HMG to 10 infertile women using two different treatment schemes. It was found that those women in whom the treatment was started earlier (e. g. on day 2 of the menstrual cycle) had significantly more follicles, including mature follicles around the assumed day of ovulation (p less than 0. 05). It was found that hyperstimulation occured on day 2 in 61% of the cycles as compared to 28% when the treatment was started on day 9. It can be concluded that: HMG therapy can override the natural selection process in women especially if it is administered prior to the selection of the dominant follicle. Early treatment with HMG is associated with a higher occurrence of hyperstimulation.