TY - JOUR
T1 - Effect of high-dose glucocorticosteroid treatment for infantile spasms on quantitative bone parameters later in life
AU - Eidlitz-Markus, Tal
AU - Kivity, Sarah
AU - Goldberg-Stern, Hadassa
AU - Haimi-Cohen, Yishai
AU - Zeharia, Avraham
PY - 2012/1
Y1 - 2012/1
N2 - This study evaluated possible long-term effects of prolonged high-dose glucocorticosteroid administration in infancy. Thirty patients (16 male, 14 female; age 4.8-33 years) who had completed treatment with adrenocorticotropic hormone (ACTH) followed by glucocorticoids for infantile spasms at a tertiary pediatric hospital at least 2 years previously were invited to undergo quantitative bone ultrasound. The mean speed of sound Z score was-1.085±1.079 for the radius and-0.22±1.19 for the tibia on the nondominant side (P =.0022). The difference from the reference mean (0) was statistically significant for the radius (P <.001). There were no significant differences in radial or tibial mean speed of sound Z scores by age (prepubertal versus pubertal/postpubertal). In conclusion, a high percentage of patients treated with glucocorticoids for infantile spasms have a low radial speed of sound Z score later in life. Long-term follow-up can help to prevent and treat impairments in bone density, especially in non- weight-bearing organs.
AB - This study evaluated possible long-term effects of prolonged high-dose glucocorticosteroid administration in infancy. Thirty patients (16 male, 14 female; age 4.8-33 years) who had completed treatment with adrenocorticotropic hormone (ACTH) followed by glucocorticoids for infantile spasms at a tertiary pediatric hospital at least 2 years previously were invited to undergo quantitative bone ultrasound. The mean speed of sound Z score was-1.085±1.079 for the radius and-0.22±1.19 for the tibia on the nondominant side (P =.0022). The difference from the reference mean (0) was statistically significant for the radius (P <.001). There were no significant differences in radial or tibial mean speed of sound Z scores by age (prepubertal versus pubertal/postpubertal). In conclusion, a high percentage of patients treated with glucocorticoids for infantile spasms have a low radial speed of sound Z score later in life. Long-term follow-up can help to prevent and treat impairments in bone density, especially in non- weight-bearing organs.
KW - ACTH
KW - High-dose glucocorticoid
KW - Infantile spasms
KW - Osteoporosis
KW - Quantitative ultrasound
KW - Speed of sound
KW - Z score
UR - http://www.scopus.com/inward/record.url?scp=84856836418&partnerID=8YFLogxK
U2 - 10.1177/0883073811413583
DO - 10.1177/0883073811413583
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C2 - 21778189
AN - SCOPUS:84856836418
SN - 0883-0738
VL - 27
SP - 74
EP - 79
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 1
ER -