Effect of Grafting on Aggregation of Intrinsically Disordered Proteins

Dino Osmanovic, Yitzhak Rabin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A significant part of the proteome is composed of intrinsically disordered proteins (IDPs). These proteins do not fold into a well-defined structure and behave like ordinary polymers. In this work, we consider IDPs that have the tendency to aggregate, model them as heteropolymers that contain a small number of associating monomers, and use computer simulations to compare the aggregation of such IDPs that are grafted to a surface or free in solution. We then discuss how such grafting may affect the analysis of in vitro experiments and could also be used to suppress harmful aggregation.

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalBiophysical Journal
Issue number3
StatePublished - 6 Feb 2018

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© 2018 Biophysical Society


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