Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells

R. Djaldetti; P. Fishman; V. Shtatlender; B. Sredni; M. Djaldetti

doi:10.1016/0753-3322(90)90172-6

Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells

R. Djaldetti
, P. Fishman
, V. Shtatlender
, B. Sredni
, M. Djaldetti

Tel Aviv University
Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [³H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids. IL-3-LA / dexamethasone / mononuclear cells.

Original language	English
Pages (from-to)	515-518
Number of pages	4
Journal	Biomedicine and Pharmacotherapy
Volume	44
Issue number	10
DOIs	https://doi.org/10.1016/0753-3322(90)90172-6
State	Published - 1990

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abstract = "The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [3H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids. IL-3-LA / dexamethasone / mononuclear cells.",

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AU - Djaldetti, M.

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AB - The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [3H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids. IL-3-LA / dexamethasone / mononuclear cells.

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Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells

Abstract

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