TY - JOUR
T1 - Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells
AU - Djaldetti, R.
AU - Fishman, P.
AU - Shtatlender, V.
AU - Sredni, B.
AU - Djaldetti, M.
PY - 1990
Y1 - 1990
N2 - The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [3H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids. IL-3-LA / dexamethasone / mononuclear cells.
AB - The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [3H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids. IL-3-LA / dexamethasone / mononuclear cells.
UR - http://www.scopus.com/inward/record.url?scp=0025696527&partnerID=8YFLogxK
U2 - 10.1016/0753-3322(90)90172-6
DO - 10.1016/0753-3322(90)90172-6
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C2 - 2085666
AN - SCOPUS:0025696527
SN - 0753-3322
VL - 44
SP - 515
EP - 518
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
IS - 10
ER -