Effect of chlorpromazine on hypothalamic-pituitary-gonadal function in 10 adolescent schizophrenic boys

A. Apter, Z. Dickerman, N. Gonen, S. Assa, R. Prager-Lewin, H. Kaufman, S. Tyano, Z. Laron

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Low basal plasma testosterone levels with normal response to human chorionic gonadotropin (HCG) stimulation and mild hyperprolactinemia and blunted luteinizing hormone (LH) response to luteinizing-releasing hormone (LRH) stimulation were found in 10 adolescent schizophrenic boys who had been treated with chlorpromazine for more than 6 months. These findings may indicate a disturbance of the hypothalamic-pituitary-gonadal function in these patients, probably due to the prolonged administration of chlorpromazine. It remains to be established whether the decrease in basal testosterone secretion is caused directly by chlorpromazine or secondarily by the drug-induced hyperprolactinemia.

Original languageEnglish
Pages (from-to)1588-1591
Number of pages4
JournalAmerican Journal of Psychiatry
Volume140
Issue number12
DOIs
StatePublished - 1983
Externally publishedYes

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