TY - JOUR
T1 - Effect of bupivacaine-induced spinal block on the hypnotic requirement of propofol
AU - Tverskoy, M.
AU - Fleyshman, G.
AU - Bachrak, L.
AU - Ben-Shlomo, I.
PY - 1996
Y1 - 1996
N2 - The hypnotic close-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.
AB - The hypnotic close-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.
KW - Anaesthesia, regional; spinal
KW - Anaesthetics, intravenous; propofol
KW - Anaesthetics, local; bupivacaine
UR - http://www.scopus.com/inward/record.url?scp=0029884954&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2044.1996.tb07847.x
DO - 10.1111/j.1365-2044.1996.tb07847.x
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C2 - 8758157
AN - SCOPUS:0029884954
SN - 0003-2409
VL - 51
SP - 652
EP - 653
JO - Anaesthesia
JF - Anaesthesia
IS - 7
ER -