Effect of bupivacaine-induced spinal block on the hypnotic requirement of propofol

M. Tverskoy, G. Fleyshman, L. Bachrak, I. Ben-Shlomo

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The hypnotic close-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.

Original languageEnglish
Pages (from-to)652-653
Number of pages2
Issue number7
StatePublished - Jul 1996
Externally publishedYes


  • Anaesthesia, regional; spinal
  • Anaesthetics, intravenous; propofol
  • Anaesthetics, local; bupivacaine


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