Effect of adjuvant tamoxifen therapy on thyroid function in postmenopausal women with breast cancer

Jamal Zidan; Wolf Rubenstein

doi:10.1159/000011928

Effect of adjuvant tamoxifen therapy on thyroid function in postmenopausal women with breast cancer

Jamal Zidan
, Wolf Rubenstein

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Serum thyroid-stimulating hormone (TSH), free thyroxine (FT₄) and total tri-iodothyronine (TT₃) concentrations were measured in 45 postmenopausal breast cancer patients before adjuvant treatment with tamoxifen and at 3- and 6-month intervals. A significant increase in TSH (p = 0.002) at the end of 3 months and a subsequent decrease at the end of 6 months was noted. There were no significant changes in TT₃ and FT₄. We concluded that tamoxifen therapy in postmenopausal women may result in a reversible increase in TSH after 3 months.

Original language	English
Pages (from-to)	43-45
Number of pages	3
Journal	Oncology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1159/000011928
State	Published - Jan 1999
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adjuvant therapy
Breast cancer
Tamoxifen
Thyroid function

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10.1159/000011928

Cite this

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title = "Effect of adjuvant tamoxifen therapy on thyroid function in postmenopausal women with breast cancer",

abstract = "Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4) and total tri-iodothyronine (TT3) concentrations were measured in 45 postmenopausal breast cancer patients before adjuvant treatment with tamoxifen and at 3- and 6-month intervals. A significant increase in TSH (p = 0.002) at the end of 3 months and a subsequent decrease at the end of 6 months was noted. There were no significant changes in TT3 and FT4. We concluded that tamoxifen therapy in postmenopausal women may result in a reversible increase in TSH after 3 months.",

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AU - Rubenstein, Wolf

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AB - Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4) and total tri-iodothyronine (TT3) concentrations were measured in 45 postmenopausal breast cancer patients before adjuvant treatment with tamoxifen and at 3- and 6-month intervals. A significant increase in TSH (p = 0.002) at the end of 3 months and a subsequent decrease at the end of 6 months was noted. There were no significant changes in TT3 and FT4. We concluded that tamoxifen therapy in postmenopausal women may result in a reversible increase in TSH after 3 months.

KW - Adjuvant therapy

KW - Breast cancer

KW - Tamoxifen

KW - Thyroid function

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ER -

Effect of adjuvant tamoxifen therapy on thyroid function in postmenopausal women with breast cancer

Abstract

UN SDGs

Keywords

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