EEG generator - A model of potentials in a volume conductor

Lilach Avitan, Mina Teicher, Moshe Abeles

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

EEG generator - a model of potentials in a volume conductor. The potential recorded over the cortex electro-corticogram (ECoG) or over the scalp [electroencephalograph (EEG)] derives from the activity of many sources known as "EEG generators." The recorded amplitude is basically a function of the unitary potential of a generator and the statistical relationship between different EEG generators in the recorded population. In this study, we first suggest a new definition of the EEG generator. We use the theory of potentials in a volume conductor and model the contribution of a single synapse activated to the surface potential. We then model the contribution of the generator to the surface potential. Once the generator and its contribution are well defined, we can quantitatively assess the degree of synchronization among generators. The measures obtained by the model for a real life scenario of a group of generators organized in a specific statistical way were consistent with the expected values that were reported experimentally. The study sheds new light on macroscopic modeling approaches which make use of mean soma membrane potential. We showed major contribution of activity of superficial apical synapses to the ECoG signal recorded relative to lower somatic or basal synapses activity.

Original languageEnglish
Pages (from-to)3046-3059
Number of pages14
JournalJournal of Neurophysiology
Volume102
Issue number5
DOIs
StatePublished - Nov 2009

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