Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications

Siva Sankar Sana, Ramakrishna Vadde, Raj Kumar, Sai Kumar Arla, Adinarayana Reddy Somala, K. S.V. Krishna Rao, Zhang Zhijun, Vijaya Kumar Naidu Boya, Kunal Mondal, Narsimha Mamidi

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.

Original languageEnglish
Article number104186
JournalJournal of Drug Delivery Science and Technology
Volume80
DOIs
StatePublished - Feb 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier B.V.

Keywords

  • Biomedical
  • Biosynthesize
  • Drug delivery
  • Green synthesis
  • Metal oxide nanoparticles
  • Zinc oxide nanoparticles

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