Eco-Friendly and Facile Preparation of Spherical Chitin Nanoparticles

John H.T. Luong, Aharon Gedanken

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A facile and eco-friendly procedure was established and optimized for the synthesis of spherical crystalline chitin nanoparticles (SChNPs) using the oxidizing agent Oxone®. This versatile triple-salt was effective in the cleavage of the glycosidic bonds and etching out individualization of elementary fibrils to form SChNPs. Selective oxidation occurred at the C6 primary hydroxyl group of the glucose molecule subunit to form carboxylic acid groups with a degree of oxidation of 0.10. The spherical particles are about 25 nm in diameter with enhanced aqueous solubility and amenable to bioconjugation owing to the presence of carboxylic acid groups. Both the acetamide group and the crystallinity index of the starting chitin remained intact during the treatment with Oxone®.

Original languageEnglish
Pages (from-to)10787-10791
Number of pages5
Issue number38
StatePublished - 17 Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


  • Oxone® monopersulfate
  • chitin nanoparticles
  • crystalline chitin
  • nanomaterials


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