Early stopping of prevention trials when multiple outcomes are of interest: A discussion

In large prevention and screening trials, we want to answer multiple questions simultaneously. When monitoring prevention trials with multiple disease outcomes, composite measures may be useful, such as a count of important events, or a comparison of expected mortality, There are advantages to investigating multiple interventions in the same prevention or screening trial, using all‐versus‐none, factorial, or reciprocal control designs. In these situations it may be important to answer some questions early while others are still being investigated.