TY - JOUR
T1 - Early stopping of prevention trials when multiple outcomes are of interest
T2 - A discussion
AU - Green, Sylvan B.
AU - Freedman, Laurence S.
PY - 1994
Y1 - 1994
N2 - In large prevention and screening trials, we want to answer multiple questions simultaneously. When monitoring prevention trials with multiple disease outcomes, composite measures may be useful, such as a count of important events, or a comparison of expected mortality, There are advantages to investigating multiple interventions in the same prevention or screening trial, using all‐versus‐none, factorial, or reciprocal control designs. In these situations it may be important to answer some questions early while others are still being investigated.
AB - In large prevention and screening trials, we want to answer multiple questions simultaneously. When monitoring prevention trials with multiple disease outcomes, composite measures may be useful, such as a count of important events, or a comparison of expected mortality, There are advantages to investigating multiple interventions in the same prevention or screening trial, using all‐versus‐none, factorial, or reciprocal control designs. In these situations it may be important to answer some questions early while others are still being investigated.
UR - http://www.scopus.com/inward/record.url?scp=0028111210&partnerID=8YFLogxK
U2 - 10.1002/sim.4780131325
DO - 10.1002/sim.4780131325
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C2 - 7973227
AN - SCOPUS:0028111210
SN - 0277-6715
VL - 13
SP - 1479
EP - 1484
JO - Statistics in Medicine
JF - Statistics in Medicine
IS - 13-14
ER -