Early prediction of the effectiveness of antidepressants: Inputs from an animal model

Alexander Friedman; Avia Merenlender; Elad Lax; Mordechay Rosenstein; Nachum Lubin; Gal Yadid

doi:10.1007/s12031-009-9176-9

Early prediction of the effectiveness of antidepressants: Inputs from an animal model

Alexander Friedman, Avia Merenlender, Elad Lax, Mordechay Rosenstein, Nachum Lubin, Gal Yadid

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Although depressive disorders affect approximately 5% of the population in developed countries each year, current antidepressants usually require several weeks to produce beneficial clinical effects and are only effective in about 55% of patients. Therefore, early prediction of the effectiveness of a particular antidepressant for a patient is important for effective pharmacological treatment of depression. In this study, we examined a new method, based on mathematical analyses, of exploratory behavior for predicting the effectiveness of particular antidepressants shortly after initiation of treatment. By using this method, we were able to predict the effectiveness of antidepressants 1-3 days after initiation of treatment in individual subjects.

Original language	English
Pages (from-to)	256-261
Number of pages	6
Journal	Journal of Molecular Neuroscience
Volume	39
Issue number	1-2
DOIs	https://doi.org/10.1007/s12031-009-9176-9
State	Published - Sep 2009

Bibliographical note

Funding Information:
Acknowledgements AF was supported by a President’s fellowship, Bar-llan University. This research reported in this article was completed as part of the first author Ph.D. dissertations.

Funding

Acknowledgements AF was supported by a President’s fellowship, Bar-llan University. This research reported in this article was completed as part of the first author Ph.D. dissertations.

Funders	Funder number
Faculty of Exact Sciences, Bar-llan University

Keywords

Antidepressants
Depression
Early onset

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10.1007/s12031-009-9176-9

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Early prediction of the effectiveness of antidepressants: Inputs from an animal model

Abstract

Bibliographical note

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Keywords

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