Early identification of acute hypoxia based on brain NADH fluorescence and cerebral blood flow

Hua Shi, Nannan Sun, Avraham Mayevsky, Zhihong Zhang, Qingming Luo

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4 Scopus citations


Hypoxia is closely related to many diseases and often leads to death. Early detection and identification of the hypoxia causes may help to promptly determine the right rescue plan and reduce the mortality. We proposed a new multiparametric monitoring method employing mitochondrial reduced nicotinamide adenine dinucleotide (NADH) fluorescence, regional reflectance, regional cerebral blood flow (CBF), electrocardiography (ECG), and respiration under six kinds of acute hypoxia in four categories to investigate a correlation between the parameter variances and the hypoxia causes. The variation patterns of the parameters were discussed, and the combination of NADH and CBF may contribute to the identification of the causes of hypoxia.

Original languageEnglish
Article number1450033
JournalJournal of Innovative Optical Health Sciences
Issue number2
StatePublished - Mar 2014
Externally publishedYes

Bibliographical note

Funding Information:
technique. And hope he will be happy to see NADH measurement has been inherited in Britton Chance Center for Biomedical Photonics. Prof. Avraham Mayevsky is on leave from The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 52900 Ramat Gan, Israel, and is supported by the 111 Project of China (B07038). This work is also supported by the Ph.D. Programs Foundation of the Ministry of Education of China (Grant No. 20110142130006) and the Director Fund of Wuhan National Laboratory for Optoelectronics (WNLO, 2009, Z.H. ZHANG).


  • Nicotinamide adenine dinucleotide fluorescence
  • acute hypoxia
  • cerebral blood flow
  • early detection


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