TY - JOUR
T1 - Early environments shape neuropeptide function
T2 - The case of oxytocin and vasopressin
AU - Perry-Paldi, Adi
AU - Hirschberger, Gilad
AU - Feldman, Ruth
AU - Zagoory-Sharon, Orna
AU - Bazak, Shira Buchris
AU - Ein-Dor, Tsachi
N1 - Publisher Copyright:
© 2019 Perry-Paldi, Hirschberger, Feldman, Zagoory-Sharon, Buchris Bazak and Ein-Dor.
PY - 2019
Y1 - 2019
N2 - Oxytocin (OT) and vasopressin (AVP) are neuropeptides that govern the social-emotional functioning of humans. We contend that to fully understand their function, research should consider how they are flexibly fitted to maximize survival and reproduction given the variety of human experience. In a series of two studies, we show that early life stress is associated with change in the core function of OT and AVP in evolutionary predictable ways: Under high early life stress, AVP promotes threat-detection capabilities, whereas OT motivates non-selective proximity seeking to others. Conversely, under low early life stress these neuropeptides have an opposite, yet adaptive response: AVP promotes low vigilance and preservation of energy, whereas OT increases detection of interpersonal flaws. Our results demonstrate the plasticity of neuropeptide functioning that mirrors the variance in human social-emotional functioning.
AB - Oxytocin (OT) and vasopressin (AVP) are neuropeptides that govern the social-emotional functioning of humans. We contend that to fully understand their function, research should consider how they are flexibly fitted to maximize survival and reproduction given the variety of human experience. In a series of two studies, we show that early life stress is associated with change in the core function of OT and AVP in evolutionary predictable ways: Under high early life stress, AVP promotes threat-detection capabilities, whereas OT motivates non-selective proximity seeking to others. Conversely, under low early life stress these neuropeptides have an opposite, yet adaptive response: AVP promotes low vigilance and preservation of energy, whereas OT increases detection of interpersonal flaws. Our results demonstrate the plasticity of neuropeptide functioning that mirrors the variance in human social-emotional functioning.
KW - Early life stress
KW - Neuropeptidal function
KW - Oxytocin
KW - Threat detection
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=85065163966&partnerID=8YFLogxK
U2 - 10.3389/fpsyg.2019.00581
DO - 10.3389/fpsyg.2019.00581
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C2 - 30949100
AN - SCOPUS:85065163966
SN - 1664-1078
VL - 10
JO - Frontiers in Psychology
JF - Frontiers in Psychology
IS - MAR
M1 - 581
ER -