E2F3-A novel repressor of the ARF/p53 pathway

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Abstract

The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf.

Original languageEnglish
Pages (from-to)742-743
Number of pages2
JournalDevelopmental Cell
Volume6
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

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