E2F1 pathways to apoptosis

Research output: Contribution to journalShort surveypeer-review

158 Scopus citations

Abstract

The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation and their activity is often deregulated in human tumors. Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1-induced apoptosis occurs via multiple pathways, some of which induce stabilization and activation of the tumor suppressor p53. The pro-apoptotic activity of E2F1 suggests that its deregulation constitutes an oncogenic stress that may target pre-malignant cells to undergo apoptosis, thus preventing tumor development.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalFEBS Letters
Volume529
Issue number1
DOIs
StatePublished - 2 Oct 2002
Externally publishedYes

Keywords

  • ApafI
  • Apoptosis
  • E2F
  • p14ARF
  • p53
  • p73

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