Abstract
The E2F family of transcription factors is most well known for its ability to regulate the expression of genes required for DNA replication and cell cycle progression. However, recent studies indicate that E2F can also regulate transcription of upstream components of signal transduction pathways. Here we discuss the effects of E2F activity on signal transduction pathways and its potential biological consequences.
| Original language | English |
|---|---|
| Pages (from-to) | 392-396 |
| Number of pages | 5 |
| Journal | Cell Cycle |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2005 |
| Externally published | Yes |
Bibliographical note
Funding Information:Work in the authors’ laboratory is supported by grants from the Israel Cancer Research Fund (ICRF) and the Israel Science Foundation. M.C. is supported by a post-doctoral fellowship from the Pasteur-Weizmann foundation. D.G. is an incumbent of the Recanati Career Development chair of Cancer research.
Funding
Work in the authors’ laboratory is supported by grants from the Israel Cancer Research Fund (ICRF) and the Israel Science Foundation. M.C. is supported by a post-doctoral fellowship from the Pasteur-Weizmann foundation. D.G. is an incumbent of the Recanati Career Development chair of Cancer research.
| Funders | Funder number |
|---|---|
| Pasteur-Weizmann foundation | |
| Israel Cancer Research Fund | |
| Israel Science Foundation |
Keywords
- E2F
- PI3-K/AKT
- Signal transduction