E2F and signal transduction pathways

Marie Chaussepied, Doron Ginsberg

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The E2F family of transcription factors is most well known for its ability to regulate the expression of genes required for DNA replication and cell cycle progression. However, recent studies indicate that E2F can also regulate transcription of upstream components of signal transduction pathways. Here we discuss the effects of E2F activity on signal transduction pathways and its potential biological consequences.

Original languageEnglish
Pages (from-to)392-396
Number of pages5
JournalCell Cycle
Issue number3
StatePublished - Mar 2005
Externally publishedYes

Bibliographical note

Funding Information:
Work in the authors’ laboratory is supported by grants from the Israel Cancer Research Fund (ICRF) and the Israel Science Foundation. M.C. is supported by a post-doctoral fellowship from the Pasteur-Weizmann foundation. D.G. is an incumbent of the Recanati Career Development chair of Cancer research.


  • E2F
  • PI3-K/AKT
  • Signal transduction


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