E23D: Database and visualization of A-to-I RNA editing sites mapped to 3D protein structures

Oz Solomon; Eran Eyal; Ninette Amariglio; Ron Unger; Gidi Rechavi

doi:10.1093/bioinformatics/btw204

E23D: Database and visualization of A-to-I RNA editing sites mapped to 3D protein structures

Oz Solomon, Eran Eyal, Ninette Amariglio, Ron Unger, Gidi Rechavi

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

e23D, a database of A-to-I RNA editing sites from human, mouse and fly mapped to evolutionary related protein 3D structures, is presented. Genomic coordinates of A-to-I RNA editing sites are converted to protein coordinates and mapped onto 3D structures from PDB or theoretical models from ModBase. e23D allows visualization of the protein structure, modeling of recoding events and orientation of the editing with respect to nearby genomic functional sites from databases of disease causing mutations and genomic polymorphism. Availability and Implementation: http://www.sheba-cancer.org.il/e23D Contact: or Eran.Eyal@sheba.health.gov.il.

Original language	English
Pages (from-to)	2213-2215
Number of pages	3
Journal	Bioinformatics
Volume	32
Issue number	14
Early online date	19 Apr 2016
DOIs	https://doi.org/10.1093/bioinformatics/btw204
State	Published - 15 Jul 2016

Bibliographical note

Funding Information:
The work was supported by grants from the Varda and Boaz Dotan Research Center in Hemato-oncology affiliated with the CBRC of Tel Aviv University, Flight Attendant Medical Research Institute (FAMRI), Israeli Centers of Excellence (I-CORE) Program (ISF grants no. 41/11 and no. 1796/12).

Publisher Copyright:
© 2016 The Author 2016. Published by Oxford University Press. All rights reserved.

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E23D: Database and visualization of A-to-I RNA editing sites mapped to 3D protein structures

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