TY - CHAP
T1 - Dynamics of the dopaminergic system as a key component to the understanding of depression
AU - Yadid, Gal
AU - Friedman, Alexander
PY - 2008
Y1 - 2008
N2 - For decades, clinical treatment of depression has usually involved antidepressants that target noradrenergic and serotonergic neurotransmission. Over the past half century, no genuinely ground-breaking progress has been made in the pharmacological development of antidepressant drugs. Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Recent findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with mathematical analysis. In this chapter comprehensive review of data from animal models, genetics, neuroimaging and human clinical trials that strengthen the case for dopaminergic dysfunction in the pathophysiology of major depression. This chapter focuses on recent convergence of data describing the fluctuation in activity of the mesolimbic dopaminergic system, and discusses its crucial role in manifestation of depressive-like behavior. Decoding the functionality of the dopaminergic system is important to the understanding of depression and the development of future efficient antidepressant treatments.
AB - For decades, clinical treatment of depression has usually involved antidepressants that target noradrenergic and serotonergic neurotransmission. Over the past half century, no genuinely ground-breaking progress has been made in the pharmacological development of antidepressant drugs. Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Recent findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with mathematical analysis. In this chapter comprehensive review of data from animal models, genetics, neuroimaging and human clinical trials that strengthen the case for dopaminergic dysfunction in the pathophysiology of major depression. This chapter focuses on recent convergence of data describing the fluctuation in activity of the mesolimbic dopaminergic system, and discusses its crucial role in manifestation of depressive-like behavior. Decoding the functionality of the dopaminergic system is important to the understanding of depression and the development of future efficient antidepressant treatments.
KW - cellular activity
KW - depressive behaviour
KW - dopamine
KW - nucleus accumbens
KW - ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=50349089560&partnerID=8YFLogxK
U2 - 10.1016/s0079-6123(08)00913-8
DO - 10.1016/s0079-6123(08)00913-8
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C2 - 18772037
AN - SCOPUS:50349089560
SN - 9780444532350
T3 - Progress in Brain Research
SP - 265
EP - 286
BT - Serotonin-Dopamine Interaction
A2 - Giovann, Giuseppe Di
A2 - Matteo, Vincenzo Di
A2 - Esposito, Ennio
ER -