Dynamics of plaque formation in Alzheimer's disease

B. Urbanc; L. Cruz; S. V. Buldyrev; S. Havlin; M. C. Irizarry; H. E. Stanley; B. T. Hyman

doi:10.1016/S0006-3495(99)77295-4

Dynamics of plaque formation in Alzheimer's disease

B. Urbanc, L. Cruz, S. V. Buldyrev, S. Havlin, M. C. Irizarry, H. E. Stanley, B. T. Hyman

Department of Physics

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-β peptide. We analyze the time evolution of amyloid- β deposition in immunostained brain slices from transgenic mice. We find that amyloid-β deposits appear in clusters whose characteristic size increases from 14 μm in 8-month-old mice to 22 μm in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-β by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.

Original language	English
Pages (from-to)	1330-1334
Number of pages	5
Journal	Biophysical Journal
Volume	76
Issue number	3
DOIs	https://doi.org/10.1016/S0006-3495(99)77295-4
State	Published - Mar 1999

Bibliographical note

Funding Information:
This paper was partly supported by National Institutes of Health grant AG08487, the National Science Foundation, and the Adler Foundation.

Funding

This paper was partly supported by National Institutes of Health grant AG08487, the National Science Foundation, and the Adler Foundation.

Funders	Funder number
National Science Foundation
National Institutes of Health
National Institute on Aging	R29AG008487
Adler Foundation

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abstract = "Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-β peptide. We analyze the time evolution of amyloid- β deposition in immunostained brain slices from transgenic mice. We find that amyloid-β deposits appear in clusters whose characteristic size increases from 14 μm in 8-month-old mice to 22 μm in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-β by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.",

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AU - Stanley, H. E.

AU - Hyman, B. T.

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Dynamics of plaque formation in Alzheimer's disease

Abstract

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