Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goal

Eyal Seidemann, Amos Arieli, Amiram Grinvald, Hamutal Slovin

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

The frontal eye field and neighboring area 8Ar of the primate cortex are involved in programming and execution of saccades. Electrical microstimulation in these regions elicits short-latency contralateral saccades. To determine how spatiotemporal dynamics of microstimulation-evoked activity are converted into saccade plans, we used a combination of real-time optical imaging and microstimulation in behaving monkeys. Short stimulation trains evoked a rapid and widespread wave of depolarization followed by unexpected large and prolonged hyperpolarization. During this hyperpolarization saccades are almost exclusively ipsilateral, suggesting an important role for hyperpolarization in determining saccade goal.

Original languageEnglish
Pages (from-to)862-865
Number of pages4
JournalScience
Volume295
Issue number5556
DOIs
StatePublished - 1 Feb 2002
Externally publishedYes

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