Dynamics and kinetics of nucleo-cytoplasmic mRNA export

Amir Mor, Yaron Shav-Tal

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Activation of the gene expression pathway in eukaryotic cells results in the nuclear transcription of mRNA molecules, many of which are destined for translation into protein by cytoplasmic ribosomes. mRNA transcripts are exported from the nucleus to the cytoplasm via passage through nuclear pore complexes (NPCs), ∼125 MDa supramolecular complexes set in the double-membraned nuclear envelope. Understanding the kinetics of mRNA translocation, from the point of transcription through export, localization, translation, and degradation, is of fundamental interest since gene expression is regulated at all the different levels of this pathway. In this review, we delineate the steps taken by an mRNA molecule in transit to the nuclear envelope and during mRNA export, with specific focus on the dynamic aspects of nucleo-cytoplasmic mRNA transport as revealed by electron microscopy and live-cell imaging.

Original languageEnglish
Pages (from-to)388-401
Number of pages14
JournalWiley interdisciplinary reviews. RNA
Volume1
Issue number3
DOIs
StatePublished - Nov 2010

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