Dynamic network interactions among distinct brain rhythms as a hallmark of physiologic state and function

Aijing Lin, Kang K.L. Liu, Ronny P. Bartsch, Plamen Ch Ivanov

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Brain rhythms are associated with a range of physiologic states, and thus, studies have traditionally focused on neuronal origin, temporal dynamics and fundamental role of individual brain rhythms, and more recently on specific pair-wise interactions. Here, we aim to understand integrated physiologic function as an emergent phenomenon of dynamic network interactions among brain rhythms. We hypothesize that brain rhythms continuously coordinate their activations to facilitate physiologic states and functions. We analyze healthy subjects during sleep, and we demonstrate the presence of stable interaction patterns among brain rhythms. Probing transient modulations in brain wave activation, we discover three classes of interaction patterns that form an ensemble representative for each sleep stage, indicating an association of each state with a specific network of brain-rhythm communications. The observations are universal across subjects and identify networks of brain-rhythm interactions as a hallmark of physiologic state and function, providing new insights on neurophysiological regulation with broad clinical implications.

Original languageEnglish
Article number197
JournalCommunications Biology
Volume3
Issue number1
DOIs
StatePublished - 27 Apr 2020

Bibliographical note

Publisher Copyright:
© 2020, The Author(s).

Funding

We acknowledge support from the National Natural Science Foundation of China (Grant no. 61673005), the W. M. Keck Foundation, National Institutes of Health (NIH Grant 1R01-HL098437), the Office of Naval Research (ONR Grant 000141010078) and the US-Israel Binational Science Foundation (BSF Grant 2012219). R.P.B. acknowledges support from a EC-FP7 Marie Curie Fellowship (IIF 628159).

FundersFunder number
EC-FP7IIF 628159
National Institutes of Health
Office of Naval Research000141010078
National Heart, Lung, and Blood InstituteR01HL098437
W. M. Keck Foundation
Bonfils-Stanton Foundation2012219
United States-Israel Binational Science Foundation
National Natural Science Foundation of China
National Natural Science Foundation of China-Yunnan Joint Fund61673005

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