Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Rakefet Ben-Yishay; Asaf J. Ashkenazy; Yaron Shav-Tal

doi:10.1016/j.tig.2016.04.003

Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Rakefet Ben-Yishay, Asaf J. Ashkenazy, Yaron Shav-Tal

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.

Original language	English
Pages (from-to)	419-431
Number of pages	13
Journal	Trends in Genetics
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.tig.2016.04.003
State	Published - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd.

Funding

Y.S.-T. is supported by the Israel Science Foundation (ISF), the United States–Israel Binational Science Foundation (BSF), and the Gassner Fund for Medical Research.

Funders	Funder number
Gassner Fund for Medical Research
United States-Israel Binational Science Foundation
Israel Science Foundation

Keywords

Chromatin
Gene tethering
MRNA dynamics
MRNA export
Nuclear pore complex

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10.1016/j.tig.2016.04.003

Cite this

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abstract = "Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.",

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Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Abstract

Bibliographical note

Funding

Keywords

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