Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Rakefet Ben-Yishay, Asaf J. Ashkenazy, Yaron Shav-Tal

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.

Original languageEnglish
Pages (from-to)419-431
Number of pages13
JournalTrends in Genetics
Issue number7
StatePublished - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd.


Y.S.-T. is supported by the Israel Science Foundation (ISF), the United States–Israel Binational Science Foundation (BSF), and the Gassner Fund for Medical Research.

FundersFunder number
Gassner Fund for Medical Research
United States-Israel Binational Science Foundation
Israel Science Foundation


    • Chromatin
    • Gene tethering
    • MRNA dynamics
    • MRNA export
    • Nuclear pore complex


    Dive into the research topics of 'Dynamic Encounters of Genes and Transcripts with the Nuclear Pore'. Together they form a unique fingerprint.

    Cite this