Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Rakefet Ben-Yishay; Asaf J. Ashkenazy; Yaron Shav-Tal

doi:10.1016/j.tig.2016.04.003

Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Rakefet Ben-Yishay, Asaf J. Ashkenazy, Yaron Shav-Tal

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.

Original language	English
Pages (from-to)	419-431
Number of pages	13
Journal	Trends in Genetics
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.tig.2016.04.003
State	Published - 1 Jul 2016

Bibliographical note

Funding Information:
Y.S.-T. is supported by the Israel Science Foundation (ISF), the United States–Israel Binational Science Foundation (BSF), and the Gassner Fund for Medical Research.

Publisher Copyright:
© 2016 Elsevier Ltd.

Keywords

Chromatin
Gene tethering
MRNA dynamics
MRNA export
Nuclear pore complex

Access to Document

10.1016/j.tig.2016.04.003

Cite this

@article{adf23f9a026445afbcf7d4fbf4e95603,

title = "Dynamic Encounters of Genes and Transcripts with the Nuclear Pore",

abstract = "Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.",

keywords = "Chromatin, Gene tethering, MRNA dynamics, MRNA export, Nuclear pore complex",

author = "Rakefet Ben-Yishay and Ashkenazy, {Asaf J.} and Yaron Shav-Tal",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.tig.2016.04.003",

language = "אנגלית",

volume = "32",

pages = "419--431",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Ltd.",

number = "7",

}

TY - JOUR

T1 - Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

AU - Ben-Yishay, Rakefet

AU - Ashkenazy, Asaf J.

AU - Shav-Tal, Yaron

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.

AB - Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.

KW - Chromatin

KW - Gene tethering

KW - MRNA dynamics

KW - MRNA export

KW - Nuclear pore complex

UR - http://www.scopus.com/inward/record.url?scp=84966702471&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2016.04.003

DO - 10.1016/j.tig.2016.04.003

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 27185238

AN - SCOPUS:84966702471

SN - 0168-9525

VL - 32

SP - 419

EP - 431

JO - Trends in Genetics

JF - Trends in Genetics

IS - 7

ER -

Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this