Abstract
Transcribed mRNA molecules must reach the cytoplasm to undergo translation. Technological developments in imaging have placed mRNAs under the spotlight, allowing the quantitative study of the spatial and temporal dynamics of the nucleocytoplasmic mRNA export process. Here, we discuss studies that have used such experimental approaches to demonstrate that gene tethering at the nuclear pore complex (NPC) regulates mRNA expression, and to characterize mRNA dynamics during transport in real time. The paths taken by mRNAs as they move from their sites of transcription and travel through the nucleoplasm, in between chromatin domains, and finally through the NPC, can now be observed in detail.
Original language | English |
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Pages (from-to) | 419-431 |
Number of pages | 13 |
Journal | Trends in Genetics |
Volume | 32 |
Issue number | 7 |
DOIs | |
State | Published - 1 Jul 2016 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Ltd.
Funding
Y.S.-T. is supported by the Israel Science Foundation (ISF), the United States–Israel Binational Science Foundation (BSF), and the Gassner Fund for Medical Research.
Funders | Funder number |
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Gassner Fund for Medical Research | |
United States-Israel Binational Science Foundation | |
Israel Science Foundation |
Keywords
- Chromatin
- Gene tethering
- MRNA dynamics
- MRNA export
- Nuclear pore complex