Single-molecule detection and spectroscopy by laser induced fluorescence offer many applications to life sciences. We review recent techniques and experiments based on the detection and spectroscopy of two near-by molecules. The spectroscopic signature of the light emitted from the two molecules can be used to measure the distance, orientation and relative dynamics between biological macromolecules.
|Number of pages||14|
|Journal||IEEE Journal of Selected Topics in Quantum Electronics|
|State||Published - Dec 1996|
Bibliographical noteFunding Information:
Manuscript received October 3, 1996; revised December 19, 1996. This work was supported by the Laboratory Directed Research and Development Program of Lawrence Berkeley National Laboratory under U.S. Department of Energy Contract DE-AC03-76SF00098 and by the Office of Naval Research under Contract N00014-95-F-0099.