Abstract
Studies investigating the mechanism of drug release from poly (fatty acid dimer:sebacic acid) {p (FAD : SA)} polyanhydride are described. Acid orange (A.O.), a hydrophilic dye and Rhodamine B Base, a hydrophobic dye, were used as models. Light microscopy indicates there is a drug depleted zone which grows wider with time. The effect of drug incorporation method on release was also investigated. An emulsion method greatly reduced A.O.'s 'burst effect'. The effect of copolymer properties (e.g., hydrophobicity, crystallinity), drug properties (e.g., solubility) and drug loading on release was also investigated. A.O. release was affected by copolymer composition, and exhibited faster release than the more hydrophobic dye, Rhodamine B Base. Correlations between drug release and underlying polymer erosion are also described.
| Original language | English |
|---|---|
| Pages (from-to) | 73-82 |
| Number of pages | 10 |
| Journal | Journal of Controlled Release |
| Volume | 29 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 1994 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors would like to thank the financial support of NIH Grant # CA5257 and a NSF graduatef ellowship. We would also like to thank Dr Ruxandra Gref for valuable discussions,D r Manoj Maniar for providing the polymersf or this study, and Irene Chen and Judy Pang for their technical assistance.
Funding
The authors would like to thank the financial support of NIH Grant # CA5257 and a NSF graduatef ellowship. We would also like to thank Dr Ruxandra Gref for valuable discussions,D r Manoj Maniar for providing the polymersf or this study, and Irene Chen and Judy Pang for their technical assistance.
| Funders | Funder number |
|---|---|
| National Science Foundation | |
| National Institutes of Health | CA5257 |
Keywords
- Biodegradable polymer matrix
- Controlled release
- Emulsion
- Polyanhydrides
- Release mechanism