TY - JOUR
T1 - Drug induced liver injury
T2 - Review with a focus on genetic factors, tissue diagnosis, and treatment options
AU - Khoury, Tawfik
AU - Rmeileh, Ayman Abu
AU - Yosha, Liron
AU - Benson, Ariel A.
AU - Daher, Saleh
AU - Mizrahi, Meir
N1 - Publisher Copyright:
© 2015 The Second Affiliated Hospital of Chongqing Medical University.
PY - 2015/6/28
Y1 - 2015/6/28
N2 - Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments.
AB - Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments.
KW - DILI
KW - Hepatotoxicity
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85089885150&partnerID=8YFLogxK
U2 - 10.14218/JCTH.2015.00007
DO - 10.14218/JCTH.2015.00007
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:85089885150
SN - 2225-0719
VL - 3
SP - 99
EP - 108
JO - Journal of Clinical and Translational Hepatology
JF - Journal of Clinical and Translational Hepatology
IS - 2
ER -
