Abstract
In this study, we investigated the drop-by-drop solvent hot antisolvent interaction (DBD-SAI) method for the production of sulfamethoxazole (SMZ) nanoparticles. We thoroughly investigated the effect of different experimental parameters. Hydroxypropyl methylcellulose (HPMC), polyacrylic acid (PAA), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and sodium dodecyl sulfate (SDS) were used as additives. From particle size and shape analysis, it was confirmed that the obtained nanoparticles of SMZ were less than 220 nm with spherical morphology, and thin circular-shaped flakes (4–5 μm) demonstrated in the presence of the additive PVP. It was observed that particle size increased with the pressure of drug solution and drug concentration and decreased with increased rate of stirring. The formulated samples demonstrated an enhanced solubility, drug-release percentage, and anti-bacterial activity compared with raw SMZ. The solubility increased a minimum of 7 times and a maximum of 18 times compared with those of raw SMZ for nano-SMZ and SMZ-PVA, respectively. The drug-release profile showed that more than 95% of SMZ was released within 1 h. Anti-bacterial activity was evaluated against gram positive bacteria Staphylococcus aureus and gram negative bacteria Escherichia Coli. SMZ-PVA showed nearly doubled anti-bacterial activity compare to raw-SMZ.
| Original language | English |
|---|---|
| Article number | 101359 |
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 55 |
| DOIs | |
| State | Published - Feb 2020 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 Elsevier B.V.
Funding
We extend our gratitude to IIT Mandi for providing laboratory facilities. The financial assistant from DRDO (Project No. ARMREB/CDSW/2012/149 ) and UGC for providing the Senior Research Fellowship to R. Kumar greatfully ackowledged. We extend our gratitude to IIT Mandi for providing laboratory facilities. The financial assistant from DRDO (Project No. ARMREB/CDSW/2012/149) and UGC for providing the Senior Research Fellowship to R. Kumar greatfully ackowledged.
| Funders | Funder number |
|---|---|
| University Grants Commission | |
| Defence Research and Development Organisation | ARMREB/CDSW/2012/149 |
| Indian Institute of Technology Mandi |
Keywords
- Bioavailability
- Dissolution
- Drug delivery
- Poor water soluble drug
- Solubility
- Sulfamethaxazole