Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers

M. L. Persson, D. Wassermann, T. Geijer, A. Frisch, R. Rockah, E. Michaelovsky, A. Apter, A. Weizmann, E. G. Jönsson, H. Bergmann

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


An association between long alleles of a variable number tandem repeat (VNTR) polymorphism in the dopamine receptor D4 gene and the extraversion related personality traits Excitement and Novelty Seeking has been reported in healthy subjects. In an attempt to replicate the previous findings, 256 healthy Caucasian volunteers were analysed for a potential relationship between the dopamine receptor D4 exon III VNTR polymorphism and Extraversion as assessed by the Revised Neo Personality Inventory (NEO PI-R). The present study did not yield evidence for an association between Extraversion and the dopamine receptor D4 polymorphism.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number4
StatePublished - 2000
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This investigation was supported by the Fred-rik and Ingrid Thuring Foundation, the Bror Gadelius Memory Fund, the Golden Gate Foundation, the Söderström-Königska Foundation, the Scandia insurance company and the Sarah and Moshe Mayer Foundation. We thank Lotta Lindström and Lars Holmberg, Centre for Suicide Research and Prevention, Kjerstin Lind and Alexandra Tylec, Psychiatry Section, Karolinska Institutet and Gunnar Hilm, Clinical Alcohol and Drug Addiction Research Section, Karolinska Hospital, for excellent technical assistance.


  • Dopamine receptor D4
  • Excitement-Seeking
  • Genetics
  • Personality inventory
  • Polymorphism


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