Does lateral parietal cortex support episodic memory?. Evidence from focal lesion patients

Patrick S.R. Davidson; David Anaki; Elisa Ciaramelli; Melanie Cohn; Alice S.N. Kim; Kelly J. Murphy; Angela K. Troyer; Morris Moscovitch; Brian Levine

doi:10.1016/j.neuropsychologia.2008.01.011

Does lateral parietal cortex support episodic memory?. Evidence from focal lesion patients

Patrick S.R. Davidson, David Anaki, Elisa Ciaramelli, Melanie Cohn, Alice S.N. Kim, Kelly J. Murphy, Angela K. Troyer, Morris Moscovitch, Brian Levine

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

Although neuroimaging and human lesion studies agree that the medial parietal region plays a critical role in episodic memory, many neuroimaging studies have also implicated lateral parietal cortex, leading some researchers to suggest that the lateral region plays a heretofore underappreciated role in episodic memory. Because there are very few extant lesion data on this matter, we examined memory in six cases of focal lateral parietal damage, using both clinical and experimental measures, in which we distinguished between recollection and familiarity. The patients did not have amnesia, but they did show evidence of disrupted recollection on an anterograde memory task. Although the exact mechanisms remain to be elucidated, lateral parietal damage appears to impair some aspects of episodic memory.

Original language	English
Pages (from-to)	1743-1755
Number of pages	13
Journal	Neuropsychologia
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.neuropsychologia.2008.01.011
State	Published - Jun 2008
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a fellowship from the Canadian Institutes of Health Research to P.S.R.D., and grants from the Canadian Institutes of Health Research to M.M. and to B.L. (grant numbers MGP-62963 and MOP-108540) and the National Institute of Child Health and Human Development to B.L. (grant number HD42385-01). We thank Adriana Restagno, Irina Nica, and Namita Kumar for retrieving patient data, Fu Qiang Gao for identifying patient lesion loci, Maroquine Aziz and Garry Wong for help preparing brain images, and Julia Spaniol for making comments on an early draft of the paper. Finally, we are grateful to the participants in this study for volunteering their time.

Funding

This work was supported by a fellowship from the Canadian Institutes of Health Research to P.S.R.D., and grants from the Canadian Institutes of Health Research to M.M. and to B.L. (grant numbers MGP-62963 and MOP-108540) and the National Institute of Child Health and Human Development to B.L. (grant number HD42385-01). We thank Adriana Restagno, Irina Nica, and Namita Kumar for retrieving patient data, Fu Qiang Gao for identifying patient lesion loci, Maroquine Aziz and Garry Wong for help preparing brain images, and Julia Spaniol for making comments on an early draft of the paper. Finally, we are grateful to the participants in this study for volunteering their time.

Funders	Funder number
National Institute of Child Health and Human Development	HD42385-01
Eunice Kennedy Shriver National Institute of Child Health and Human Development	R01HD042385
Canadian Institutes of Health Research	MOP-108540, MGP-62963

Keywords

Autobiographical memory
Recollection
Retrosplenial cortex
Working memory
fMRI

Access to Document

10.1016/j.neuropsychologia.2008.01.011

Cite this

@article{eb2c5aabea40402880c050987718517a,

title = "Does lateral parietal cortex support episodic memory?. Evidence from focal lesion patients",

abstract = "Although neuroimaging and human lesion studies agree that the medial parietal region plays a critical role in episodic memory, many neuroimaging studies have also implicated lateral parietal cortex, leading some researchers to suggest that the lateral region plays a heretofore underappreciated role in episodic memory. Because there are very few extant lesion data on this matter, we examined memory in six cases of focal lateral parietal damage, using both clinical and experimental measures, in which we distinguished between recollection and familiarity. The patients did not have amnesia, but they did show evidence of disrupted recollection on an anterograde memory task. Although the exact mechanisms remain to be elucidated, lateral parietal damage appears to impair some aspects of episodic memory.",

keywords = "Autobiographical memory, Recollection, Retrosplenial cortex, Working memory, fMRI",

author = "Davidson, {Patrick S.R.} and David Anaki and Elisa Ciaramelli and Melanie Cohn and Kim, {Alice S.N.} and Murphy, {Kelly J.} and Troyer, {Angela K.} and Morris Moscovitch and Brian Levine",

note = "Funding Information: This work was supported by a fellowship from the Canadian Institutes of Health Research to P.S.R.D., and grants from the Canadian Institutes of Health Research to M.M. and to B.L. (grant numbers MGP-62963 and MOP-108540) and the National Institute of Child Health and Human Development to B.L. (grant number HD42385-01). We thank Adriana Restagno, Irina Nica, and Namita Kumar for retrieving patient data, Fu Qiang Gao for identifying patient lesion loci, Maroquine Aziz and Garry Wong for help preparing brain images, and Julia Spaniol for making comments on an early draft of the paper. Finally, we are grateful to the participants in this study for volunteering their time. ",

year = "2008",

month = jun,

doi = "10.1016/j.neuropsychologia.2008.01.011",

language = "אנגלית",

volume = "46",

pages = "1743--1755",

journal = "Neuropsychologia",

issn = "0028-3932",

publisher = "Elsevier Ltd.",

number = "7",

}

TY - JOUR

T1 - Does lateral parietal cortex support episodic memory?. Evidence from focal lesion patients

AU - Davidson, Patrick S.R.

AU - Anaki, David

AU - Ciaramelli, Elisa

AU - Cohn, Melanie

AU - Kim, Alice S.N.

AU - Murphy, Kelly J.

AU - Troyer, Angela K.

AU - Moscovitch, Morris

AU - Levine, Brian

N1 - Funding Information: This work was supported by a fellowship from the Canadian Institutes of Health Research to P.S.R.D., and grants from the Canadian Institutes of Health Research to M.M. and to B.L. (grant numbers MGP-62963 and MOP-108540) and the National Institute of Child Health and Human Development to B.L. (grant number HD42385-01). We thank Adriana Restagno, Irina Nica, and Namita Kumar for retrieving patient data, Fu Qiang Gao for identifying patient lesion loci, Maroquine Aziz and Garry Wong for help preparing brain images, and Julia Spaniol for making comments on an early draft of the paper. Finally, we are grateful to the participants in this study for volunteering their time.

PY - 2008/6

Y1 - 2008/6

N2 - Although neuroimaging and human lesion studies agree that the medial parietal region plays a critical role in episodic memory, many neuroimaging studies have also implicated lateral parietal cortex, leading some researchers to suggest that the lateral region plays a heretofore underappreciated role in episodic memory. Because there are very few extant lesion data on this matter, we examined memory in six cases of focal lateral parietal damage, using both clinical and experimental measures, in which we distinguished between recollection and familiarity. The patients did not have amnesia, but they did show evidence of disrupted recollection on an anterograde memory task. Although the exact mechanisms remain to be elucidated, lateral parietal damage appears to impair some aspects of episodic memory.

AB - Although neuroimaging and human lesion studies agree that the medial parietal region plays a critical role in episodic memory, many neuroimaging studies have also implicated lateral parietal cortex, leading some researchers to suggest that the lateral region plays a heretofore underappreciated role in episodic memory. Because there are very few extant lesion data on this matter, we examined memory in six cases of focal lateral parietal damage, using both clinical and experimental measures, in which we distinguished between recollection and familiarity. The patients did not have amnesia, but they did show evidence of disrupted recollection on an anterograde memory task. Although the exact mechanisms remain to be elucidated, lateral parietal damage appears to impair some aspects of episodic memory.

KW - Autobiographical memory

KW - Recollection

KW - Retrosplenial cortex

KW - Working memory

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=44349094751&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2008.01.011

DO - 10.1016/j.neuropsychologia.2008.01.011

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 18313699

AN - SCOPUS:44349094751

SN - 0028-3932

VL - 46

SP - 1743

EP - 1755

JO - Neuropsychologia

JF - Neuropsychologia

IS - 7

ER -

Does lateral parietal cortex support episodic memory?. Evidence from focal lesion patients

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this