DNA in nanopores: Counterion condensation and coion depletion

Yitzhak Rabin, Motohiko Tanaka

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Molecular dynamics simulations are used to study the equilibrium distribution of monovalent ions in a nanopore connecting two water reservoirs separated by a membrane, both for the empty pore and that with a single stranded DNA molecule inside. In the presence of DNA, the counterions condense on the stretched macromolecule effectively neutralizing it, and nearly complete depletion of coions from the pore is observed. The implications of our results for experiments on DNA translocation through α-hemolysin nanopores are discussed.

Original languageEnglish
Article number148103
JournalPhysical Review Letters
Issue number14
StatePublished - 15 Apr 2005


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