TY - JOUR
T1 - DNA in nanopores
T2 - Counterion condensation and coion depletion
AU - Rabin, Yitzhak
AU - Tanaka, Motohiko
PY - 2005/4/15
Y1 - 2005/4/15
N2 - Molecular dynamics simulations are used to study the equilibrium distribution of monovalent ions in a nanopore connecting two water reservoirs separated by a membrane, both for the empty pore and that with a single stranded DNA molecule inside. In the presence of DNA, the counterions condense on the stretched macromolecule effectively neutralizing it, and nearly complete depletion of coions from the pore is observed. The implications of our results for experiments on DNA translocation through α-hemolysin nanopores are discussed.
AB - Molecular dynamics simulations are used to study the equilibrium distribution of monovalent ions in a nanopore connecting two water reservoirs separated by a membrane, both for the empty pore and that with a single stranded DNA molecule inside. In the presence of DNA, the counterions condense on the stretched macromolecule effectively neutralizing it, and nearly complete depletion of coions from the pore is observed. The implications of our results for experiments on DNA translocation through α-hemolysin nanopores are discussed.
UR - http://www.scopus.com/inward/record.url?scp=18144387608&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.94.148103
DO - 10.1103/PhysRevLett.94.148103
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C2 - 15904117
AN - SCOPUS:18144387608
SN - 0031-9007
VL - 94
JO - Physical Review Letters
JF - Physical Review Letters
IS - 14
M1 - 148103
ER -