TY - JOUR
T1 - Diversity and functional landscapes in the microbiota of animals in the wild
AU - Levin, Doron
AU - Raab, Neta
AU - Pinto, Yishay
AU - Rothschild, Daphna
AU - Zanir, Gal
AU - Godneva, Anastasia
AU - Mellul, Nadav
AU - Futorian, David
AU - Gal, Doran
AU - Leviatan, Sigal
AU - Zeevi, David
AU - Bachelet, Ido
AU - Segal, Eran
N1 - Publisher Copyright:
© 2021 American Association for the Advancement of Science. All rights reserved.
PY - 2021/4/16
Y1 - 2021/4/16
N2 - Animals in the wild are able to subsist on pathogen-infected and poisonous food and show immunity to various diseases. These may be due to their microbiota, yet we have a poor understanding of animal microbial diversity and function. We used metagenomics to analyze the gut microbiota of more than 180 species in the wild, covering diverse classes, feeding behaviors, geographies, and traits. Using de novo metagenome assembly, we constructed and functionally annotated a database of more than 5000 genomes, comprising 1209 bacterial species of which 75% are unknown. The microbial composition, diversity, and functional content exhibit associations with animal taxonomy, diet, activity, social structure, and life span. We identify the gut microbiota of wild animals as a largely untapped resource for the discovery of therapeutics and biotechnology applications.
AB - Animals in the wild are able to subsist on pathogen-infected and poisonous food and show immunity to various diseases. These may be due to their microbiota, yet we have a poor understanding of animal microbial diversity and function. We used metagenomics to analyze the gut microbiota of more than 180 species in the wild, covering diverse classes, feeding behaviors, geographies, and traits. Using de novo metagenome assembly, we constructed and functionally annotated a database of more than 5000 genomes, comprising 1209 bacterial species of which 75% are unknown. The microbial composition, diversity, and functional content exhibit associations with animal taxonomy, diet, activity, social structure, and life span. We identify the gut microbiota of wild animals as a largely untapped resource for the discovery of therapeutics and biotechnology applications.
UR - http://www.scopus.com/inward/record.url?scp=85104872055&partnerID=8YFLogxK
U2 - 10.1126/science.abb5352originally
DO - 10.1126/science.abb5352originally
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C2 - 33766942
AN - SCOPUS:85104900642
SN - 0036-8075
VL - 372
JO - Science
JF - Science
IS - 6539
M1 - eabb5352
ER -