Abstract
Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn.
Original language | English |
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Pages (from-to) | 880-888 |
Number of pages | 9 |
Journal | Nature Immunology |
Volume | 16 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2015 |
Bibliographical note
Publisher Copyright:© 2015, Nature Publishing Group. All rights reserved.
Funding
We thank U. Kalinke (TWINCORE, Hannover, Germany), A. Krueger, I. Prinz, O. Schulz, S. Woltemate (Hannover Medical School, Hannover, Germany), M. Bemark (University of Gothenburg, Gothenburg, Sweden), B. Wabakken Hognestad and D. Ölsner (both at the Norwegian University of Life Sciences, Oslo, Norway), and R. Bharti (IKMB, University of Kiel, Kiel, Germany). This work was supported by the DFG Cluster of Excellence Inflammation at Interfaces (CL VIII to P.R., S.O. and S. Schreiber), the BMBF (grant SysINFLAME (TP3/4) to P.R.), the Israel Science Foundation (grant 270/09 to R.M.), the German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig and Deutsche Forschungsgemeinschaft (grants PA921/4-1 (to O.P.) and SFB621-Z).
Funders | Funder number |
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DFG Cluster of Excellence Inflammation at Interfaces | |
German Centre for Infection Research | |
Deutsches Zentrum für Infektionsforschung | |
Deutsche Forschungsgemeinschaft | SFB621-Z, PA921/4-1 |
Bundesministerium für Bildung und Forschung | TP3/4 |
Israel Science Foundation | 270/09 |