Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis

Rama Falk, Jacob Grunwald, Amnon Hoffman, Abraham J. Domb, Itzhack Polacheck

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.

Original languageEnglish
Pages (from-to)3606-3609
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

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