Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar, Jessica Rose, Burcu Aykac Fas, Nir Ben-Tal, Oded Lewinson, Turkan Haliloglu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Long-range allosteric communication are essential to the function of molecular machines. Here, Acar et al. studied long-range communications in ABC transporters, and discovered that, despite the similar architecture of the transporters, each uses a very different communications network that is fine-tuned to its specific physiological role.

Original languageEnglish
Pages (from-to)651-663.e5
JournalStructure
Volume28
Issue number6
DOIs
StatePublished - 2 Jun 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020

Funding

This work was supported by grants from NATO Science for Peace and Security Program (SPS project G4622 , to O.L., T.H., and N.B.-T.), the Israeli Academy of Sciences project 1006/18 (to O.L. and J.R.), the United States-Israel Binational Science Foundation (BSF) project 2015102 (to O.L. and J.R.), TÜBITAK (The Scientific and Technological Research Council of Turkey) under grant no. 115M418 (to T.H., B.A., and B.A.F.), Boğaziçi University Research Fund BAP project no. 11160 (to T.H., B.A., and B.A.F.), and the Rappaport Family Institute for biomedical research (to O.L. and J.R.).

FundersFunder number
Israeli Academy of Sciences1006/18
NATO Science for Peace and Security Program
Rappaport Family Institute
United States-Israel Binational Science Foundation2015102
Saudi Pharmaceutical SocietyG4622
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu115M418
Boğaziçi Üniversitesi11160

    Keywords

    • ABC transporter
    • ANM
    • ANM-LD
    • ATP hydrolysis
    • allostery
    • membrane protein
    • molecular dynamics
    • transport

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