Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar, Jessica Rose, Burcu Aykac Fas, Nir Ben-Tal, Oded Lewinson, Turkan Haliloglu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Long-range allosteric communication are essential to the function of molecular machines. Here, Acar et al. studied long-range communications in ABC transporters, and discovered that, despite the similar architecture of the transporters, each uses a very different communications network that is fine-tuned to its specific physiological role.

Original languageEnglish
Pages (from-to)651-663.e5
Issue number6
StatePublished - 2 Jun 2020
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from NATO Science for Peace and Security Program (SPS project G4622 , to O.L., T.H., and N.B.-T.), the Israeli Academy of Sciences project 1006/18 (to O.L. and J.R.), the United States-Israel Binational Science Foundation (BSF) project 2015102 (to O.L. and J.R.), TÜBITAK (The Scientific and Technological Research Council of Turkey) under grant no. 115M418 (to T.H., B.A., and B.A.F.), Boğaziçi University Research Fund BAP project no. 11160 (to T.H., B.A., and B.A.F.), and the Rappaport Family Institute for biomedical research (to O.L. and J.R.).

Publisher Copyright:
© 2020


  • ABC transporter
  • ANM
  • ANM-LD
  • ATP hydrolysis
  • allostery
  • membrane protein
  • molecular dynamics
  • transport


Dive into the research topics of 'Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters'. Together they form a unique fingerprint.

Cite this