Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar; Jessica Rose; Burcu Aykac Fas; Nir Ben-Tal; Oded Lewinson; Turkan Haliloglu

doi:10.1016/j.str.2020.03.014

Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar, Jessica Rose, Burcu Aykac Fas, Nir Ben-Tal, Oded Lewinson, Turkan Haliloglu

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Long-range allosteric communication are essential to the function of molecular machines. Here, Acar et al. studied long-range communications in ABC transporters, and discovered that, despite the similar architecture of the transporters, each uses a very different communications network that is fine-tuned to its specific physiological role.

Original language	English
Pages (from-to)	651-663.e5
Journal	Structure
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.str.2020.03.014
State	Published - 2 Jun 2020
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from NATO Science for Peace and Security Program (SPS project G4622 , to O.L., T.H., and N.B.-T.), the Israeli Academy of Sciences project 1006/18 (to O.L. and J.R.), the United States-Israel Binational Science Foundation (BSF) project 2015102 (to O.L. and J.R.), TÜBITAK (The Scientific and Technological Research Council of Turkey) under grant no. 115M418 (to T.H., B.A., and B.A.F.), Boğaziçi University Research Fund BAP project no. 11160 (to T.H., B.A., and B.A.F.), and the Rappaport Family Institute for biomedical research (to O.L. and J.R.).

Publisher Copyright:
© 2020

Keywords

ABC transporter
ANM
ANM-LD
ATP hydrolysis
allostery
membrane protein
molecular dynamics
transport

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10.1016/j.str.2020.03.014

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Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Abstract

Bibliographical note

Keywords

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