TY - JOUR
T1 - Disentangling the genetic determinants of human aging
T2 - Biological age as an alternative to the use of survival measures
AU - Karasik, David
AU - Demissie, Serkalem
AU - Cupples, L. Adrienne
AU - Kiel, Douglas P.
PY - 2005/5
Y1 - 2005/5
N2 - The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%. The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans.
AB - The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%. The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans.
UR - http://www.scopus.com/inward/record.url?scp=20544472174&partnerID=8YFLogxK
U2 - 10.1093/gerona/60.5.574
DO - 10.1093/gerona/60.5.574
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AN - SCOPUS:20544472174
SN - 1079-5006
VL - 60
SP - 574
EP - 587
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 5
ER -