Disentangling early sensory information processing deficits in schizophrenia

Anthony J. Rissling; David L. Braff; Neal R. Swerdlow; Gerhard Hellemann; Yuri Rassovsky; Joyce Sprock; Marlena Pela; Gregory A. Light

doi:10.1016/j.clinph.2012.02.079

Disentangling early sensory information processing deficits in schizophrenia

Anthony J. Rissling, David L. Braff, Neal R. Swerdlow, Gerhard Hellemann, Yuri Rassovsky, Joyce Sprock, Marlena Pela, Gregory A. Light

Department of Psychology

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62 Scopus citations

Abstract

Objective: The disentangling of early sensory information processing deficits and examination of their relationships to demographic and clinical factors are important steps for the validation of potential biomarkers and/or endophenotypes of schizophrenia. The aims of the present study were to characterize commonly used sensory event-related potential deficits, to determine whether they are (1) distinct from one another and (2) independently associated with important clinical characteristics. Methods: MMN, P3a and RON event-related potentials (ERP) were recorded from schizophrenia patients (SZ; n=429) and nonpsychiatric comparison subjects (NCS; n=286). Subgroup analyses on demographic and clinical variables were performed. Results: Schizophrenia patients exhibited robust ERP deficits at frontocentral electrodes (MMN: d=1.10; P3a: d=0.87; RON: d=0.77), consistent with previous studies. Each ERP component uniquely accounted for variance in amplitude and schizophrenia deficits. Amplitude reductions occurred with increasing age in both NCS and SZ patients. A small subset of patients prescribed combinations of 1st and 2nd generation antipsychotics exhibited significantly reduced MMN amplitude relative to other medication-defined subgroups. Conclusions: MMN, P3a, and RON are dissociable deficits with distinct relationships to age and medication status in schizophrenia patients, potentially reflecting divergent pathophysiological processes. Reduced MMN in patients taking multiple antipsychotic medications appear to be attributable to greater severity of symptoms and functional impairments, rather than a medication effect. Significance: Independent information processing deficits in schizophrenia patients may differentially contribute to the commonly observed deficits in neurocognitive and psychosocial functioning.

Original language	English
Pages (from-to)	1942-1949
Number of pages	8
Journal	Clinical Neurophysiology
Volume	123
Issue number	10
DOIs	https://doi.org/10.1016/j.clinph.2012.02.079
State	Published - Oct 2012

Bibliographical note

Funding Information:
This work was supported by the National Alliance for Research on Schizophrenia and Depression , and grants from the Department of Veteran Affairs (VISN 22 Mental Illness Research, Education, and Clinical Center) and National Institute of Mental Health ( MH079777 , MH042228 and MH065571 ). The authors wish to Richard Sharp for his assistance.

Keywords

Attention
Event related potentials
Mismatch negativity
P300
Reorienting negativity

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10.1016/j.clinph.2012.02.079

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title = "Disentangling early sensory information processing deficits in schizophrenia",

abstract = "Objective: The disentangling of early sensory information processing deficits and examination of their relationships to demographic and clinical factors are important steps for the validation of potential biomarkers and/or endophenotypes of schizophrenia. The aims of the present study were to characterize commonly used sensory event-related potential deficits, to determine whether they are (1) distinct from one another and (2) independently associated with important clinical characteristics. Methods: MMN, P3a and RON event-related potentials (ERP) were recorded from schizophrenia patients (SZ; n=429) and nonpsychiatric comparison subjects (NCS; n=286). Subgroup analyses on demographic and clinical variables were performed. Results: Schizophrenia patients exhibited robust ERP deficits at frontocentral electrodes (MMN: d=1.10; P3a: d=0.87; RON: d=0.77), consistent with previous studies. Each ERP component uniquely accounted for variance in amplitude and schizophrenia deficits. Amplitude reductions occurred with increasing age in both NCS and SZ patients. A small subset of patients prescribed combinations of 1st and 2nd generation antipsychotics exhibited significantly reduced MMN amplitude relative to other medication-defined subgroups. Conclusions: MMN, P3a, and RON are dissociable deficits with distinct relationships to age and medication status in schizophrenia patients, potentially reflecting divergent pathophysiological processes. Reduced MMN in patients taking multiple antipsychotic medications appear to be attributable to greater severity of symptoms and functional impairments, rather than a medication effect. Significance: Independent information processing deficits in schizophrenia patients may differentially contribute to the commonly observed deficits in neurocognitive and psychosocial functioning.",

keywords = "Attention, Event related potentials, Mismatch negativity, P300, Reorienting negativity",

author = "Rissling, {Anthony J.} and Braff, {David L.} and Swerdlow, {Neal R.} and Gerhard Hellemann and Yuri Rassovsky and Joyce Sprock and Marlena Pela and Light, {Gregory A.}",

note = "Funding Information: This work was supported by the National Alliance for Research on Schizophrenia and Depression , and grants from the Department of Veteran Affairs (VISN 22 Mental Illness Research, Education, and Clinical Center) and National Institute of Mental Health ( MH079777 , MH042228 and MH065571 ). The authors wish to Richard Sharp for his assistance. ",

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AU - Hellemann, Gerhard

AU - Rassovsky, Yuri

AU - Sprock, Joyce

AU - Pela, Marlena

AU - Light, Gregory A.

N1 - Funding Information: This work was supported by the National Alliance for Research on Schizophrenia and Depression , and grants from the Department of Veteran Affairs (VISN 22 Mental Illness Research, Education, and Clinical Center) and National Institute of Mental Health ( MH079777 , MH042228 and MH065571 ). The authors wish to Richard Sharp for his assistance.

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N2 - Objective: The disentangling of early sensory information processing deficits and examination of their relationships to demographic and clinical factors are important steps for the validation of potential biomarkers and/or endophenotypes of schizophrenia. The aims of the present study were to characterize commonly used sensory event-related potential deficits, to determine whether they are (1) distinct from one another and (2) independently associated with important clinical characteristics. Methods: MMN, P3a and RON event-related potentials (ERP) were recorded from schizophrenia patients (SZ; n=429) and nonpsychiatric comparison subjects (NCS; n=286). Subgroup analyses on demographic and clinical variables were performed. Results: Schizophrenia patients exhibited robust ERP deficits at frontocentral electrodes (MMN: d=1.10; P3a: d=0.87; RON: d=0.77), consistent with previous studies. Each ERP component uniquely accounted for variance in amplitude and schizophrenia deficits. Amplitude reductions occurred with increasing age in both NCS and SZ patients. A small subset of patients prescribed combinations of 1st and 2nd generation antipsychotics exhibited significantly reduced MMN amplitude relative to other medication-defined subgroups. Conclusions: MMN, P3a, and RON are dissociable deficits with distinct relationships to age and medication status in schizophrenia patients, potentially reflecting divergent pathophysiological processes. Reduced MMN in patients taking multiple antipsychotic medications appear to be attributable to greater severity of symptoms and functional impairments, rather than a medication effect. Significance: Independent information processing deficits in schizophrenia patients may differentially contribute to the commonly observed deficits in neurocognitive and psychosocial functioning.

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Disentangling early sensory information processing deficits in schizophrenia

Abstract

Bibliographical note

Keywords

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