Abstract
Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as cytotoxic action against a number of cancer cell lines.
Original language | English |
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Pages (from-to) | 15042-15044 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 127 |
Issue number | 43 |
DOIs | |
State | Published - 2 Nov 2005 |