TY - JOUR
T1 - Disaggregation, stabilization, and innovative functionalization/surface engineering of detonation nanodiamonds via ultrasonication-promoted ceric ammonium nitrate treatment
AU - Itshak-Levy, Daniel
AU - Israel, L. L.
AU - Schmerling, B.
AU - Kannan, S.
AU - Sade, H.
AU - Michaeli, S.
AU - Lellouche, Jean Paul
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/4
Y1 - 2020/4
N2 - We present a novel method for aqueous effective disaggregation, dispersion, and stabilization of detonation nanodiamonds (NDs) that also allows easy further second-step nanodiamond (ND) functionalization/surface engineering through lanthanide-based coordination chemistry. This method includes ultrasonic irradiation of NDs in the presence of a strong mono-electronic ceric ammonium nitrate (CAN, [Ce(IV)(NH4)2(NO3)6]) oxidant. The resulting CAN-treated NDs are positively charged with lanthanide [CeLn]3/4+ complexes/cations, enabling an anti-aggregation effect together with the ability to be further surface-modified through [CeLn]3/4+ ligand exchange (lanthanide coordinative chemistry). Therefore, this method produces ~10 nm-sized CAN-modified nanoparticles (NDs-CAN NPs) that are highly positively charged (ξ potential maximal value: +45.7 mV & average zeta potential: +34.6 mV). The obtained ND surface modification by [CeLn]3/4+ complexes/cations enabled an organic-type coordination attachment of various different organic molecules. This innovative way of dealing with the well-known ND aggregation phenomenon enables a novel way for the development of a wide range of biomedical, imaging, and diagnostic-related ND-based applications.
AB - We present a novel method for aqueous effective disaggregation, dispersion, and stabilization of detonation nanodiamonds (NDs) that also allows easy further second-step nanodiamond (ND) functionalization/surface engineering through lanthanide-based coordination chemistry. This method includes ultrasonic irradiation of NDs in the presence of a strong mono-electronic ceric ammonium nitrate (CAN, [Ce(IV)(NH4)2(NO3)6]) oxidant. The resulting CAN-treated NDs are positively charged with lanthanide [CeLn]3/4+ complexes/cations, enabling an anti-aggregation effect together with the ability to be further surface-modified through [CeLn]3/4+ ligand exchange (lanthanide coordinative chemistry). Therefore, this method produces ~10 nm-sized CAN-modified nanoparticles (NDs-CAN NPs) that are highly positively charged (ξ potential maximal value: +45.7 mV & average zeta potential: +34.6 mV). The obtained ND surface modification by [CeLn]3/4+ complexes/cations enabled an organic-type coordination attachment of various different organic molecules. This innovative way of dealing with the well-known ND aggregation phenomenon enables a novel way for the development of a wide range of biomedical, imaging, and diagnostic-related ND-based applications.
KW - Disaggregation
KW - Functional nanodiamonds
KW - Nanodiamond surface functionalization/engineering
UR - http://www.scopus.com/inward/record.url?scp=85078697086&partnerID=8YFLogxK
U2 - 10.1016/j.diamond.2020.107738
DO - 10.1016/j.diamond.2020.107738
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AN - SCOPUS:85078697086
SN - 0925-9635
VL - 104
JO - Diamond and Related Materials
JF - Diamond and Related Materials
M1 - 107738
ER -