Direction of magnetoencephalography sources associated with feedback and feedforward contributions in a visual object recognition task

Seppo P. Ahlfors; Stephanie R. Jones; Jyrki Ahveninen; Matti S. Hämäläinen; John W. Belliveau; Moshe Bar

doi:10.1016/j.neulet.2014.11.029

Direction of magnetoencephalography sources associated with feedback and feedforward contributions in a visual object recognition task

Seppo P. Ahlfors, Stephanie R. Jones, Jyrki Ahveninen, Matti S. Hämäläinen, John W. Belliveau, Moshe Bar

The Leslie and Susan Gonda Multidisciplinary Brain Research Center

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Identifying inter-area communication in terms of the hierarchical organization of functional brain areas is of considerable interest in human neuroimaging. Previous studies have suggested that the direction of magneto- and electroencephalography (MEG, EEG) source currents depend on the layer-specific input patterns into a cortical area. We examined the direction in MEG source currents in a visual object recognition experiment in which there were specific expectations of activation in the fusiform region being driven by either feedforward or feedback inputs. The source for the early non-specific visual evoked response, presumably corresponding to feedforward driven activity, pointed outward, i.e., away from the white matter. In contrast, the source for the later, object-recognition related signals, expected to be driven by feedback inputs, pointed inward, toward the white matter. Associating specific features of the MEG/EEG source waveforms to feedforward and feedback inputs could provide unique information about the activation patterns within hierarchically organized cortical areas.

Original language	English
Pages (from-to)	149-154
Number of pages	6
Journal	Neuroscience Letters
Volume	585
DOIs	https://doi.org/10.1016/j.neulet.2014.11.029
State	Published - 12 Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ireland Ltd.

Funding

This work was supported by NIH grants NS57500 (SPA), NS37462 (JWB/SPA), EY019477 (MB), and The Israeli Center of Research Excellence in Cognitive Sciences ICORE grant No. 51/11 (MB). This work was supported in part by The National Center for Research Resources ( P41EB015896 ). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Funders	Funder number
Israeli Center of Research Excellence in Cognitive Sciences	51/11
National Institutes of Health	EY019477, NS37462
National Institute of Neurological Disorders and Stroke	R56NS057500
National Center for Research Resources	P41EB015896

Keywords

Bottom-up
Cerebral cortex
Current dipole
Magnetoencephalography
Top-down

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10.1016/j.neulet.2014.11.029

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abstract = "Identifying inter-area communication in terms of the hierarchical organization of functional brain areas is of considerable interest in human neuroimaging. Previous studies have suggested that the direction of magneto- and electroencephalography (MEG, EEG) source currents depend on the layer-specific input patterns into a cortical area. We examined the direction in MEG source currents in a visual object recognition experiment in which there were specific expectations of activation in the fusiform region being driven by either feedforward or feedback inputs. The source for the early non-specific visual evoked response, presumably corresponding to feedforward driven activity, pointed outward, i.e., away from the white matter. In contrast, the source for the later, object-recognition related signals, expected to be driven by feedback inputs, pointed inward, toward the white matter. Associating specific features of the MEG/EEG source waveforms to feedforward and feedback inputs could provide unique information about the activation patterns within hierarchically organized cortical areas.",

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AU - Belliveau, John W.

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Direction of magnetoencephalography sources associated with feedback and feedforward contributions in a visual object recognition task

Abstract

Bibliographical note

Funding

Keywords

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