Direct sequencing of the human microbiome readily reveals community differences

Justin Kuczynski; Elizabeth K. Costello; Diana R. Nemergut; Jesse Zaneveld; Christian L. Lauber; Dan Knights; Omry Koren; Noah Fierer; Scott T. Kelley; Ruth E. Ley; Jeffrey I. Gordon; Rob Knight

doi:10.1186/gb-2010-11-5-210

Direct sequencing of the human microbiome readily reveals community differences

Justin Kuczynski, Elizabeth K. Costello, Diana R. Nemergut, Jesse Zaneveld, Christian L. Lauber, Dan Knights, Omry Koren, Noah Fierer, Scott T. Kelley, Ruth E. Ley, Jeffrey I. Gordon, Rob Knight

Research output: Contribution to journal › Review article › peer-review

135 Scopus citations

Abstract

Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

Original language	English
Article number	210
Journal	Genome Biology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1186/gb-2010-11-5-210
State	Published - 5 May 2010
Externally published	Yes

Bibliographical note

Funding Information:
We thank the Crohn’s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.

Funding

We thank the Crohn’s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.

Funders	Funder number
National Institutes of Health
Howard Hughes Medical Institute
National Institute of General Medical Sciences	T32GM008759
Bill and Melinda Gates Foundation
Crohn's and Colitis Foundation of America

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10.1186/gb-2010-11-5-210

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title = "Direct sequencing of the human microbiome readily reveals community differences",

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AU - Costello, Elizabeth K.

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AU - Zaneveld, Jesse

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AU - Knights, Dan

AU - Koren, Omry

AU - Fierer, Noah

AU - Kelley, Scott T.

AU - Ley, Ruth E.

AU - Gordon, Jeffrey I.

AU - Knight, Rob

N1 - Funding Information: We thank the Crohn’s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.

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AB - Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

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Direct sequencing of the human microbiome readily reveals community differences

Abstract

Bibliographical note

Funding

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