Direct sequencing of the human microbiome readily reveals community differences

Justin Kuczynski, Elizabeth K. Costello, Diana R. Nemergut, Jesse Zaneveld, Christian L. Lauber, Dan Knights, Omry Koren, Noah Fierer, Scott T. Kelley, Ruth E. Ley, Jeffrey I. Gordon, Rob Knight

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations


Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

Original languageEnglish
Article number210
JournalGenome Biology
Issue number5
StatePublished - 5 May 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank the Crohn’s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.


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